Endocrine Abstracts

Current therapeutics target cGMP in treating erectile dysfunction and other cardiovascular disorders. In the endocrine system, cGMP mediates the vast majority of biological effects of the natriuretic peptides (ANP, BNP and CNP) acting via their specific guanylyl cyclases receptors (GC-A and GC-B). There are severe endocrine consequences for mice and humans exhibiting mutations to GC-B receptors, including achondroplasia, growth hormone deficiency and female infertility. Despit...